Systematic review and pharmacoeconomic evaluation of compound calcium carbonate granules in treatment of nutritional rickets
ZHAN Meng-ru
LI Yan
TIAN Chen-hui
ZHANG Rui-hao
CAO Yi
CHEN Ping-yu
Abstract：Objective:To conduct a systematic review and pharmacoeconomic evaluation to analyze the effectiveness,safety,and cost-effectiveness of compound calcium carbonate granules in the treatment of nutritional rickets,providing clinical recommendations for the treatment of this condition.Methods:A network Meta-analysis was performed to compare the effectiveness and safety of different treatment regimens,and a decision tree model was constructed for cost-effectiveness analysis.Results:The Meta-analysis indicated that compound calcium carbonate granules were superior to calcium carbonate D3 granules in terms of efficacy,relapse rate,and bone mineral density Z-scores,with no significant difference in safety.Pharmacoeconomic evaluation revealed that the incremental cost-effectiveness ratio(ICER)of compound calcium carbonate granules compared to calcium carbonate D3 granules was 4261.91 yuan per case,and 4244.73 yuan per case compared to pediatric calcium carbonate D3 granules.Sensitivity analysis results were consistent with the base-case analysis.Conclusion:Compound calcium carbonate granules demonstrate superior efficacy in treating nutritional rickets compared to calcium carbonate D3 granules,with comparable safety profiles.Furthermore,compound calcium carbonate granules are highly likely to be cost-effective for this indication.
Keywords：compound calcium carbonate granulescalcium carbonate D3 granulesnutritional ricketsMeta analysiscost-effectiveness analysis
Publication Date：2025-06-30
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：10( 1322-1331 )