Improvement of dissolvability of Tongsaimai granules based on AHP-CRITIC weight analysis and mixing design method
WANG Sheng-hua
WANG Shu-juan
YAN Ming
WANG Xin
ZHANG Chen-feng
WANG Zhen-zhong
ZHOU En-li
XIAO Wei
Abstract：Objective:To optimize the ratio of drug to drug and improve the solubility of Tongsaimai granules.Methods:The resting angle,hygroscopic rate,molding rate,melting rate and particle solution state of Tongsaimai granules were taken as evaluation indexes.Analytical hierarchy process(AHP)was used to determine the weight coefficient of each evaluation index based on the criteria importance through intercriteria correlation(CRITIC)and AHP-CRITIC mixed weighting method.In order to improve the solubility of Tongsaimai granules,the mixture design was used to optimize the mixture ratio.The physical fingerprint was constructed to verify the secondary physical properties of batch particles,and the consistency of particle quality attributes between batches was evaluated.Results:The weight coefficients of particle melting rate,solution state,molding rate,angle of rest and moisture absorption obtained by AHP-CRITIC mixed weighting method were 0.296 6,0.369 2,0.063 8,0.169 9,and 0.100 6,respectively.Combined with the mixing design results,the optimal ratio of Tongsaimai granules was determined to be Tongsaimai dry powder∶mannitol=15∶2.The physical fingerprint of the validated batch was constructed based on the drug supplement ratio.The results showed that the similarity of physical properties between batches was greater than 0.9,and the difference between batches was small.Conclusion:The optimized Tongsaimai granules have good solubility and high consistency of physical properties between batches,which can improve the solubility of production process preparations.
Keywords：Tongsaimai granulesanalytical hierarchy process methodcriteria importance through intercriteria correlation methodanalytical hierarchy process-criteria importance through intercriteria correlation hybrid weighting methodmixing designdissolvability
Publication Date：2025-06-30
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：9( 1280-1288 )