Research on the degradation characteristics of polymers in implants and their impact on drug release behavior
LU Shu-yu
YIN Jie
DI Bin
YIN Li-hui
Abstract：Implantable drug delivery system is a novel type of sustained/controlled-release drug delivery system,offering unique advantages of long-term continuous and stable drug release,good patient compliance,and high bioavailability.Implants have been widely applied in various fields,including long-term pain management,cancer treatment,ophthalmic disease treatment,cardiovascular disease treatment,and reproductive health.With the research and development of polymer materials in recent years,polymers with good biocompatibility,such as polylactic acid,polyglycolic acid,polycaprolactone,and polylactic acid-glycolic acid copolymer,have been gradually used in the preparation and production of implants.Studies indicate that the inherent properties of these polymers have a certain impact on the drug release of implants.In this paper,the types,degradation/drug release mechanisms and their influencing factors,as well as clinical applications of polymers commonly used in implantable systems are reviewed,aiming to provide a reference for further optimizing the sustained/controlled-release mode of implants,establishing in vitro release methods that have better correlation with in vivo conditions for implants,and promoting the application of new polymer materials in implants.
Keywords：implantspolymersdegradation mechanismsdrug release behaviorquality controladditives
Publication Date：2025-06-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：14( 1185-1198 )