Efficacy and safety of Compound Cortex Phellodendri Liquid for herpes zoster:a Meta-analysis
WANG Yue-mei
WU Ning-bo
ZHU Ya-meng
LI Pei-sai
LI Ling-e
Abstract：Objective:To conduct a Meta-analysis to evaluate the clinical efficacy and safety of Compound Cortex Phellodendri Liquid for treatment of herpes zoster,thus to provide evidence-based medical evidence for clinical treatment of herpes zoster.Methods:Databases including PubMed,Embase,the Cochrane Library,CNKI,and Wanfang were searched to collect randomized controlled trials(RCTs)about Compound Cortex Phellodendri Liquid in the treatment of herpes zoster from inception to March 2022.Meta-analysis was performed by using RevMan5.3 statistical software.Results:A total of eight RCTs involving 568 patients were included.The result of Meta-analysis showed that Compound Cortex Phellodendri Liquid produced a statistically significant improvement for a higher effective rate in Herpes zoster(RR=1.46,95%CI(1.23,1.74),P<0.00001).Two studies described the analgesic time and scab forming time of the experimental group and the control group,and there was significant difference between the two groups(P<0.05).Two articles described the VAS scores of the experimental group and the control group,and there was significant difference between the two groups(P<0.05).One study described herpes zoster rash scores in the experimental and control groups.After treatment,the herpes zoster rash scores(the number of blisters,number of blisters,change of blisters,and the area of erythema of the two groups were lower than those of the control group(P<0.05).One study described the comparison of the levels of IL-2,IL-6,IL-8,and PGE2 between the experimental group and the control group.After treatment,the levels of IL-2,IL-6,IL-8,and PGE2 in the experimental group were lower than those in the control group(P<0.05).One study described the treatment satisfaction of two groups of patients.The results showed that 88.6%of the satisfaction in the experimental group was higher than 60.0%in the control group,and there was significant difference between the two groups(P<0.05).One study described the occurrence of adverse reactions in the experimental group and the control group.Conclusion:Compound Cortex Phellodendri Fluid is an effective and safe external preparation for treating herpes zoster.More high-quality RCTs need to be carried out to confirm the present findings.
Keywords：Compound Cortex Phellodendri Liquidherpes zosterefficacysafetyMeta-analysis
Publication Date：2025-05-30
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 1116-1120 )