Optimization of extraction process of Yinqi Qingwen Formula based on network pharmacology combined with entropy weight analysis
ZHANG Ya-xuan
YUAN Rui
SHEN Hui-juan
ZHONG Wan-ling
FAN Xiao-yu
YE Jin-hong
MA Yun-nan
BAI Jie
DU Shou-ying
Abstract：Objective:To optimize the extraction process of Yinqi Qingwen Formula by using network pharmacology combined with multi-index orthogonal experiments.Methods:We screened potential active ingredients and targets of Yinqi Qingwen Formula through network pharmacology and molecular docking technology,and determied indicator ingredients based on the formula solution and reference to the Pharmacopoeia of the People's Republic of China(2020 edition).The orthogonal experiment was conducted using water addition ratio,extraction times,and extraction time as influencing factors.The transfer rate of key indicator components served as evaluation indicators.The information entropy weighting method was used to calculate and comprehensively evaluate the optimal extraction process of Yinqi Qingwen Formula.Results:The identified marker components were identified as chlorogenic acid,isochlorogenic acid A,and isochlorogenic acid C.The optimized extraction of Yinqi Qingwen Formula was to extract twice,each time for 1 hour,adding 12 times of water and 9 times of water,respectively.Conclusion:It is rational and feasible to optimize the extraction process of Yinqi Qingwen Formula through network pharmacology and molecular docking technology.The optimized extraction is stable and repeatable,which can provide a reference for its follow-up research and development.
Keywords：Yinqi Qingwen Formulaextraction processnetwork pharmacologymolecular dockinginformation entropy weighting methodorthogonal design
Publication Date：2025-05-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：12( 961-972 )