Applications of benchtop NMR in drug analysis
PU Heng-ting
LI Jie
ZHANG Na
YU Li-ju
LIU Yang
Abstract：Benchtop NMR,as a crucial analytical method,is widely used in pharmaceutical analysis due to its non-destructive nature,rapid analysis speed,non-necessary of sample pretreatment,and ease of use.This technology is applied in drug structure identification,content determination,illicit drug detection,drug metabolism studies,and chemical reaction monitoring,showing significant potential in pharmaceutical analysis.This review summarizes the research background,significance,basic principles,and precausions for quantitative analysis of benchtop NMR,evaluates its cost-effectiveness,explores its specific applications in pharmaceutical analysis,and discusses its prospects.With technological advancements,the limitations of benchtop NMR are expected to be gradually overcome,further driving innovation in drug development and quality control,and providing more efficient research methods for pharmaceutical research.
Keywords：benchtop NMRdrug analysiscontent determinationillicit drug detectiondrug metabolism studieschemical reaction monitoring
Publication Date：2025-04-30
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 837-842 )