Exploring the mechanism of anti-cholestasis of Chinese medicine based on farnesol X receptor
TANG Yin-pei
ZHU Zheng-wang
WANG Lin-lin
ZHAO Jing-han
WANG Bing
ZHU Ping-sheng
Abstract：Cholestasis is a pathology common to many acute and chronic liver diseases and is mainly characterized by excessive accumulation of bile components such as bile acids(BAs)in the liver and body circulation.Clinical manifestations are jaundice,fatigue and itching,etc.The condition is protracted and difficult to cure.If not intervened in time,persistent cholestasis can further develop into liver fibrosis,cirrhosis,liver failure and even end-stage liver disease.The pathogenesis of cholestasis is complex,and there is a lack of effective therapeutic drugs.Recent studies have shown that farnesol X receptor(FXR)plays an important role in the development of cholestasis by regulating the synthesis,transport,metabolism,and reabsorption of BAs,the major components of bile,and has gradually become a hot target in the research and development of anti-cholestasis drugs.Traditional Chinese medicine(TCM)is safe,effective and has few side effects,and with the gradual deepening of research,the efficacy of TCM active ingredients or combinations in regulating FXR against cholestasis is remarkable.Through literature search and summarization,the authors systematically explored the research progress of FXR receptor-based anti-cholestasis of TCM active ingredients and combinations,with a view to providing ideas and references for the treatment of cholestasis and related drug development.
Keywords：cholestasisbile acidsfarnesol X receptortraditional Chinese medicinemechanism
Publication Date：2025-04-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：7( 706-712 )