Current research status and future application prospects of organ-on-a-chip technology in pharmacokinetics
LI Yi-zhi
SHEN Shao-lei
WANG Hui-hao
WANG Jun-long
LIU Li
Abstract：Accurate prediction of pharmacokinetic parameters is crucial for the successful development of novel drugs.Traditional pharmacokinetic studies mainly utilized animals models;however,due to species differences in structure and physiology between animals and humans,the prediction of human pharmacokinetic parameters from animal experiments falls short of expectations.In recent years,the development of organ-on-a-chip(OOC)has shown considerable potential as an in vitro method for predicting pharmacokinetic and pharmacodynamic parameters in humans by constructing in vitro microphysiological systems utilizing human-derived cells.It has the potential to recapitulate key physiological parameters in the human body.This paper systematically introduces the current research status of single-chip models and multichip models in the field of pharmacokinetics,and also discusses the reliability of the translation of OOC models to in vivo circumstance,providing an overview of the both the challenges of organ-on-a-chip and the prospects for their application.
Keywords：microfluidicorgan-on-a-chipmicrophysiological systempharmacokineticspharmacodynamics
Publication Date：2025-04-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：7( 699-705 )