Analysis of the main technological pathways in the organoid field based on patent citation networks
ZHANG Ting
CHEN Juan
LU Yan
XU Dong-zi
OUYANG Zhao-lian
Abstract：Objective:To explore the main paths on technological development in the organoid field based on patent citation networks.Methods:This study constructs a patent citation network for the organoid field and applies the search path link count(SPLC)algorithm to calculate traversal weights for main path analysis,aiming to investigate the technological development trajectory in this area.Results:The organoid field includes 2,250 patent applications and 12,722 patent citations.The number of patent applications has been increasing annually,with the technological developments focused on disease models,drug screening,cell culture and organoid chip.Main path analysis reveals that the most patents,twelve in total,appear on the global main path,which contains one technological route consistent with the global key-route path.While the local forward main path contains ten patents,with one technological route,reflecting China's technological trajectory in organoid development,focusing on disease mechanism research based on tumor organoids,as well as development and optimization of lung cancer organoid models.The local backward main path contains nine patents and two technological routes,reflecting the American trajectory in organoid technology,focusing on gastrointestinal organoid cultivation and disease models,stem cell-driven organ function repair,as well as cell transplantation and organ regeneration.Conclusion:This study identifies technological development trajectories through main path analysis of patents in the organoid field,providing intelligence support for R&D in organoids from a perspective of information science.
Keywords：organoidspatent citation networkmain path analysissearch path link count
Publication Date：2025-04-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：9( 684-692 )