Research advances and quality considerations in stem cell-derived extracellular vesicles
GONG Xu
CHEN Hao
WANG Jing-yu
LU Jia-qi
WEI Wei
Abstract：Stem cell-derived extracellular vesicles(EV)are lipid bilayer structures secreted by stem cells via paracrine mechanisms.These vesicles possess the potential to promote tissue regeneration and modulate immune responses,positioning them as promising alternatives to stem cell therapy.Given the current ambiguity surrounding EV definitions,the lack of standardized guidelines for quality assessment,and challenges in clinical translation,this paper aims to elucidate their fundamental concepts,summarize their applications in clinical trials for various diseases,analyze critical quality control parameters,and discuss the opportunities and challenges faced by researchers during clinical translation.It is anticipated that with technological advancement and industry standardization,stem cell-derived EV will play a pivotal role in clinical therapeutics and drive innovation in the biomedical sector.
Keywords：stem cellsextracellular vesiclesquality studyclinical trial
Publication Date：2025-03-30
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 625-630 )