Literature analysis of adverse drug reactions induced by pazopanib

ZHANG Xiao-xin; WU Ming-ming; RUAN Xian-mei

doi:10.20251/j.cnki.1003-3734.2025.05.015

Abstract：Objective:To analyze the clinical characteristics and patterns of adverse drug reactions(ADR)of pazopanib,in order to provide a reference for the clinical safety of this drug.Methods:The databases of PubMed,CNKI,Wanfang and VIP were searched,and the literatures reporting adverse reactions caused by pazopanib were collected and analyzed.The studied period was from inception to March 2024.Results:A total of 84 literatures were included,involving 89 cases,reporting 94 ADR,among which 21 ADR were new.There were 55 male(61.80%)and34 female(38.20%).Average age of patients was(57.7±16.7)years old.Pazopanib was mainly used for suprarenal epithelioma,accounting for 58.43%;followed by soft tissue sarcoma,accounting for 35.96%.Most of them occurred within 60 days after drug administration(55/94,58.51%).Organs/systems involved in ADR were mostly diseases of skin and subcutaneous tissue(accounting for 22.34%),followed by diseases of hepatobiliary pancreatic system(13.83%),respiratory system(12.77%)and nervous system(12.77%)which mainly manifested as posterior reversible encephalopathy syndrome and aerothorax.Five cases of pazopanib-induced ADR were recovered without doing anything(5.43%);74 cases were recovered after drug therapy(80.43%);8 cases had sequel after surgery,disease course and therapy prolonged(8.70%);and 5 death cases(5.43%).Conclusion:Pazopanib-induced ADR involve various organs/systems,and fatal cases.In the process of clinical medication,we should strengthen the observation and monitoring,as well as timely ADR disposal,to guarantee the safety of patients.