Signal mining and analysis of adverse drug events of intravenous and oral iron preparations in some city
MA Si-jia
LI Xing-qiao
Abstract：Objective:To provide reference for clinical safe drug use by signal mining and analysis of adverse drug events(ADEs)of intravenous and oral iron preparations.Methods:Based on the reports in Chengdu database of the National Adverse Drug Reaction Monitoring System from the first quarter of 2011 to the fourth quarter of 2023,the adverse drug reaction signals produced by iron sucrose injection,iron dextran injection,polysaccharide iron complex,and ferrous succinate were mined.The reporting odds ratio(ROR)method was used to mine and analyze the related data.Results:Thirty-six ADE signals were found by ROR signal detection method,which had high correlation strength between iron sucrose injection and iron dextran injection,mainly involving injection site reaction,systemic administration reaction,disease of respiratory system and allergic reaction.However,polysaccharide iron complex and ferrous succinate-related ADEs were mainly associated with gastrointestinal damage.Conclusion:The organs/systems involved with the ADE signals of four kinds of iron preparations are different,and the analysis of the data can provide help for clinical drug selection.
Keywords：intravenous ironoral ironreporting odds ratiosignal miningadverse drug event
Publication Date：2025-02-27
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 444-448 )