A review of pharmacoeconomic evaluation on oral and intravenous dosage forms of drugs with the same chemical name or category

LIU Chang; WEI Jia-yin; WU Yao; WANG Fang-xu; SUN Shuang; TAO Li-bo

doi:10.20251/j.cnki.1003-3734.2025.04.017

Abstract：Objective:Based on the literatures on pharmacoeconomic evaluation of oral and intravenous dosage forms of drugs with the same chemical name or category for the treatment of the same disease,this article analyzes and discusses how to quantify the differences caused by different dosage forms in pharmacoeconomic evaluation.Methods:The relevant literature on pharmacoeconomic evaluation of oral and intravenous dosage forms was collected from online database CNKI,Wanfang Data,Vip,PubMed,Wiley online library,etc.,and the literature meeting the standard of inclusion and exclusion criteria was sorted out and summarized.Results:A total of 18 literatures were included in the study.The result suggested that compared with the intravenous dosage form,the oral dosage form not only saves the cost of consumables such as intravenous syringes and infusion tubes,reduce nursing time and save human resources,but also saves the cost of medical transportation and loss of work hour under the scenario of home treatment.In addition,some studies also considered that oral dosage forms can improve the patients'health effectiveness and medication compliance,thus their health benefits were included in the calculation of economic evaluation.Conclusion:Differences in dosage forms may lead to differences in cost,efficacy and incidence of complications,which should be reasonably quantified and reflected in pharmacoeconomic evaluation.In addition,in the case of different treatment scenarios(such as inpatient intravenous injection and home oral administration),the treatment experience of patients with different dosage forms may be remarkably different,which should be included in the calculation of drug evaluation studies.