Preparation and quality evaluation of lansoprazole enteric orally disintegrating tablets
HE Yan-ni
JIANG Chuan-zhen
WU Xiu-ning
WANG Dong-kai
Abstract：Objective:To study the preparation and quality evaluation of lansoprazole enteric orally disintegrating tablets.Methods:The formulation was optimized by orthogonal design,using the comprehensive score of friability,disintegration time,and dissolution in acid at 60 min as index.Results:The best formula was composed of microcrystalline cellulose 20%,magnesium stearate 2%,crospovidone 7%,and lansoprazole enteric pellets 15% .The friability,disintegration time,assay and content uniformity of the three batches conformed to the requirements.Samples were put at 40℃condition for 6 months,and there was no significant change in friability,disintegration time,assay,impurity,and dissolution.Conclusion:The lansoprazole enteric orally disintegrating tablets prepared by the optimized method has a flat appearance and stable quality.
Keywords：lansoprazoleenteric orally disintegrating tabletspellets compressionorthogonal teststability
Publication Date：2025-02-27
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 414-418 )