A study on the preventive and therapeutic effects of Xiang Huo Spray on upper respiratory tract infections in mice
LI Ting
YAN Hong
GONG Lv-dong
ZHONG Cheng-zhi
LIN Rui-chao
ZHU Gao-qian
SUN Wen-qiang
WU De-song
GUO Yan
Abstract：Objective:To investigate the prevention and treatment effect of Xiang Huo Spray(XHS)on upper respiratory tract infection in mice.Methods:The anticough and expectorant effects of XHS and its effect for improvement of acute rhinitis were evaluated by using concentrated ammonia water cough model,phenol red excretion model and acute rhinitis model induced by xylene in mice.The release of pro-inflammatory mediators from mouse macrophages induced by LPS,disk diffusion and double dilution method were used to detect the anti-inflammatory and antibacterial effect of XHS on major respiratory pathogens in vitro.Results:XHS can significantly reduce the frequency of cough and increase the amount of phenol red in the trachea of mice,improve the pathological changes of acute rhinitis in mice,and reduce inflammation and bleeding.XHS can significantly inhibit the release of pro-inflammatory mediators and has obvious antibacterial activity against major respiratory pathogens in vitro,showing good anti-inflammatory and antibacterial effects in vitro.Conclusion:XHS has the pharmacological effects of relieving cough and resolving phlegm,anti-inflammation and antibacterial.It can significantly improve the pathological changes of acute rhinitis in mice,reduce inflammation and bleeding,and has a certain prevention and treatment effect on upper respiratory tract infection.
Keywords：Xiang Huo Sprayupper respiratory tract infectionscough and phlegmacute rhinitisantibacterialanti-inflammatory
Publication Date：2025-02-27
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：7( 407-413 )