Literature review and analysis of adverse drug reactions induced by obinutuzumab
ZHU Wen-jing
GUO Chao
ZHU Wen-bing
WANG Jun-ping
Abstract：Objective:To analyze the situation and clinical characteristics of adverse drug reactions(ADRs)induced by obinutuzumab to provide references for clinical medication safety.Methods:PubMed,Web of Science,CNKI,VIP and Wanfang databases were searched for ADRs induced by obinutuzumab,and the collected literatures were further analyzed statistically.Results:Totally 17 papers were included,involving 23 patients(9 males and 14 females).The patients'ages ranged from 35 to 83 years.Patients of 61 to 70 years accounted for the highest proportion(n=7,30.43%).ADRs of obinutuzumab frequently occurred in the first medication cycle(n=14,60.87%).The main clinical manifestations of the 23 patients were disorders of the immune system(n=10)and hematologic disorders(n=9).Moreover,there were new adverse reactions,for example,Richter's syndrome and apoptotic enteropathy.Fifteen patients improved or recovered after discontinuation of medication and/or symptomatic support.Conclusion:The risk factors associated with ADRs should be carefully evaluated in the clinical use of obinutuzumab to improve patient medication safety.
Keywords：obinutuzumabadverse drug reactionsliterature analysis
Publication Date：2025-01-29
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：7( 210-216 )