CFD simulation of the flow field of agitators at different eccentric distances of stirring paddles
TIAN Bo-lin
XIA Zhen-yan
LI Jin
CHANG Yi-zhuo
NING Bao-ming
ZHAO Hai-shan
Abstract：Objective:To investigate the impact of the eccentric distance of stirring paddles on the flow field characteristics of dissolution vessels during drug dissolution testing.Methods:Computational fluid dynamics(CFD)was used to simulate the speed of the stirring paddle of 100 r·min-1,and the flow field of the stirring device at different eccentric distances was calculated and analyzed.Results:When the eccentricity distance was not more than 1 mm,the simulation results showed that no significant difference was observed for the flow field velocity and strain rate at different eccentricity distances,and when the eccentricity distance reached 2 mm,the velocity and strain rate distribution of the flow field changed significantly.Conclusion:This method is suitable for quantitative observation of the correlation between eccentricity distance and flow field.
Keywords：drug dissolutiondissolution vesselsstirring paddlescomputational fluid dynamics simulationflow fieldeccentricitystrain rate
Publication Date：2025-01-29
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：7( 166-172 )