Clinical effect of Gecko Remediation Lung Tablets in the prevention and treatment of radiation pneumonia

JIANG Wen-ting; GAO Li-juan; BAO Wen-bin; SONG Li-li; SHI Shao-qing; HOU Bo-qun; WANG Xin-li; LI Zhi; ZHANG Xue-liang; SONG Wei-shan; WANG Di; YU Yan

doi:10.20251/j.cnki.1003-3734.2025.02.008

Abstract：Objective:To explore the therapeutic effect of Gecko Remediation Lung Tablets in the prevention and treatment of radiation pneumonitis.Methods:Sixty primary lung cancer patients with radical radiation therapy admitted to Jiamusi Cancer Hospital from December 2022 to December 2023 were selected and divided into experimental group and control group by random number table,with 30 in each group.Both groups received conformate intensity-modulated radiation therapy(IMRT).The patients in the experimental group were treated with lung tablets during radiotherapy.From the onset of radiation therapy,the occurrence of radiation pneumonia and the improvement of lung function in the two groups were compared.Results:The incidence of radiation pneumonitis in the experimental group was significantly lower than that in the control group(P<0.05);the total effective rate of TCM symptom improvement in the experimental group was significantly higher than that in the control group(P<0.05).Before treatment,there was no statistically significant difference in the maximum ventilation volume(MVV),forced vital capacity(FVC),and resting ventilation volume per minute(VE)between the two groups of patients(P>0.05).After treatment,the MVV,FVC,and VE of the patients in the experimental group were significantly higher than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups of patients(P>0.05).No serious adverse events occurred in either group.The incidence of patchy consolidation,blurred edges,thickened lung texture,and disordered lung texture in the experimental group under CT imaging was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).Before radiotherapy,there was no significant difference in blood routine indicators between the experimental group and the control group(P>0.05).After radiotherapy,there was no significant difference in blood routine indicators between the experimental group and the control group(P>0.05).There was no statistically significant difference in the indicators of white blood cells,hemoglobin,platelets,etc.in the blood routine between the two groups before and after radiotherapy(P>0.05).There was no significant difference in urine routine indicators between the experimental group and the control group before and after radiotherapy(P>0.05).Conclusion:Gecko Remediation Lung Tablets have significant effects in the clinical treatment of lung cancer radiotherapy patients,which can effectively prevent radiation pneumonia,improve patients'clinical symptoms,enhance their lung function level,and have good safety.It is worthy of clinical application.