Advances in carrier-free self-assembled nanomedicines of berberine
ZHANG Ai-lin
GUAN Feng
LI Wei-nan
HAN Feng-juan
WANG Yan-hong
Abstract：Berberine(BBR),as an active ingredient of traditional Chinese medicine with significant medicinal value,is limited in clinical application due to low solubility and poor bioavailability.Chemical modification or nanocarrier delivery methods are often used to overcome these challenges.However,despite the advantages of nanocarrier delivery,it is also accompanied by problems such as premature drug leakage,limited drug loading,and potential toxicity.Carrier-free nanomedicine has attracted extensive attention as a green,safe and simple delivery strategy,which not only avoids the potential risks of traditional nanocarriers,but also makes up for the shortcomings of nanocarrier delivery with excellent high drug loading capacity and excellent biocompatibility.The research and development of carrier-free self-assembly nanomedicine products of BBR,as an active ingredient of traditional Chinese medicine with strong self-assembly ability and excellent pharmacological effects,has attracted much attention.The purpose of this article is to summarize the combination strategy of BBR carrier-free self-assembled nanomedicine and its performance in practical application,hoping to further promote the modernization of traditional Chinese medicine and the development of new drugs.
Keywords：berberineactive ingredient of traditional Chinese medicineself-assemblycarrier-freenanomedicineapplication
Publication Date：2025-01-29
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 153-158 )