Process research on the formula granules of Cinnamomum migao

YUAN Hong-fei; XIAO Jin-chao; ZHOU Jia-hua; HUANG Yong; LI Yue-ting; CHI Ming-yan; ZHENG Lin

doi:10.20251/j.cnki.1003-3734.2025.01.012

Abstract：Objective:The traditional decoction process was used to extract Cinnamomum migao,and the effective part of volatile oil and water extraction was retained simultaneously. The preparation process of the formula granules of Cinnamomum migao was further studied. Methods:Taking water addition,extraction time and extraction times as the investigation factors,the contents of four components,such as salidroside,and the dry paste rate as evaluation indexes,the Box-Behnken response surface method was used to optimize the extraction process of Cinnamomum migao. Taking β-cyclodextrin-oil ratio,inclusion temperature,and inclusion time as the factors to be investigated,the contents of eucalyptol and p-cymene and the yield of inclusion complexes as evaluation indexes,the inclusion process of β-cyclodextrin in Cinnamomum migao oil was optimized in orthogonal experiments. After the aqueous extract of Cinnamomum migao was concentrated and dried,the inclusion complex was added to the intermediate in proportion,and the formula granules were obtained by dry granulation. Results:The optimized extraction process of Cinnamomum migao was adding 12 times of water for 1 st decoction and 10 times water for 2 nd decoctions,cooking for 1 h each time,and then combining the filtrates,and collecting an appropriate amount of volatile oil at the same time. After orthogonal test investigation and verification,8 times the amount of volatile oil was finally added to β-cyclodextrin. After coated for 60 min at 40℃,the β-cyclodextrin inclusion complex of ginger oil was prepared. The aqueous extract of Cinnamomum migao was concentrated to a relative density of 1.04～1.10 under reduced pressure at 65 ℃,and the intermediate of the dry extract was obtained after vacuum drying and crushing. The formula granules of Cinnamomum migao were obtained by dry granulation after the crude drug amount of 0.34％ inclusion complex was added. Conclusion:The process conditions of the formula granules were stable and feasible,which can provide data support for the preparation and industrial production of the formula granules of Cinnamomum migao.