Efficacy and safety analysis of acute and subacute eczema patients treated with compound Huangbai liquid application:a multicenter,randomized,double-blind and placebo-controlled clinical trial
ZENG Bi-jun
LIU Yi
WANG Yu-yi
YAN Xiao-ning
ZHANG Xiao-jie
CAO Yi
YANG Zhi-bo
Abstract：Objective:To observe the efficacy and safety of compound Huangbai liquid for the patients with acute and subacute eczema.Methods:A hundred and twenty patients with acute and subacute eczema,who met the inclusion and exclusion criteria and were admitted to 5 centers including the Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine,were enrolled in the randomized clinical trial which concluded a treatment group(n=60)and a control group(n=60).The patients in treatment group received compound Huangbai liquid,while the control group was given compound Huangbai liquid placebo.After one week of treatment,the total symptom score(TSS),eczema area and severity index(EASI),visual analogue scale(VAS),traditional Chinese medicine symptom score,and safety were evaluated in the two groups.Results:Finally,101 cases,50 cases in experimental group and 51 cases in control group,were included.On the 4th and 7th days after treatment,TSS,EASI and VAS were improved and the rate of traditional Chinese medicine symptoms in treatment group were significantly higher than that in control group at the same period(P<0.05).The symptoms such as itching,erythema,papules,erosion,and exudation in treatment group were significantly improved compared to those in control group(P<0.05).The total effective rate of treatment group(78%)was significantly higher than that of control group(9.8%,P<0.05).There was no statistically significant difference in the incidence of adverse events between the patients of two groups(P>0.05).Conclusion:Compound Huangbai liquid can accelerate the relief of various symptoms in patients with acute and subacute eczema,and has a definite and safe and reliable therapeutic effect.
Keywords：compound Huangbai liquideczemaerosionexudate
Publication Date：2024-12-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 2489-2494 )