Research progress of enzyme-responsive peptide self-assembly for tumor imaging
WU Yu-jing
ZHOU Peng
WU Hao
XIE Min-hao
Abstract：Tumor imaging plays a crucial role in the non-invasive diagnosis and monitoring of cancer,providing visual information essential for early detection,localization,and staging.It is pivotal for improving the survival rates and enhancing the life quality for cancer patients.The enzyme-responsive peptide self-assembly strategy,by inducing the in-situ formation of probe molecules into nanostructures,facilitates the aggregation and retention of imaging probes in tumors,thereby enhancing the accuracy and sensitivity of tumor imaging.This review comprehensively outlines the design principles and recent advancements of enzyme-responsive peptide self-assembling probes of tumor imaging.Encompassing multiple imaging modalities,including fluorescence imaging(FI),magnetic resonance imaging(MRI),and positron emission tomography(PET),the review also discusses the approaches for expanding the applicability of this strategy to diverse tumor targets.
Keywords：peptide self-assemblytumor imagingfluorescence imagingmagnetic resonance imagingpositron emission tomography
Publication Date：2024-12-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：7( 2482-2488 )