Study on application of new clinical pathology markers in assessment of drug-induced non-clinical gastrointestinal dysfunction
CHEN Tao
ZHANG Yan
LI Hua
Abstract：Objective:To establish a comprehensive,non-invasive,rapid and accurate serological method for evaluating gastrointestinal dysfunction in animals.Methods:After establishing the model of gastrointestinal injury in SD rats,blood samples were collected to detect the serum levels of pepsinogen(PG),gastrin(G-17),citrulline(Cit)and intestinal fatty acid binding protein(I-FABP),at the same time,the histopathology of stomach and intestines were examined to explore the correlation between the pathological results and the serological results.Results:Compared with the control group,the serum levels of PGⅠ,Cit,I-FABP and PGⅠ/PGⅡ ratio were decreased(P<0.05),while serum levels of PGⅡ(P<0.05)and G-17(P<0.01)were increased in the model group.Conclusion:PG,G-17,Cit,I-FABP can be used in the early diagnosis of gastrointestinal dysfunction in non-clinical evaluation of drugs.
Keywords：non-clinical evaluationgastrointestinal dysfunctionclinical pathology
Publication Date：2024-10-31
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：4( 2149-2152 )