Efficacy and safety of butylphthalide in the treatment of aphasia after cerebral infarction:a Meta-analysis
HU Yi-bin
ZHANG Li-juan
ZHANG Hai-xuan
MA Yi-zheng
XU Yi-qun
WANG Kang-feng
Abstract：Objective:To evaluate the efficacy and safety of butylphthalide in the treatment of aphasia after cerebral infarction.Methods:The databases such as CNKI,Wanfang database,VIP database,China biomedical literature database,PubMed,Web of Science,and Embase were searched from the establishment of each database to March 1,2024.The literature was screened,data were extracted,and Revman 5.4 software was used for quality evaluation and Meta-analysis.Results:A total of 25 studies involving 2 248 patients were included.The results of Meta-analysis showed that the NIHSS score of the intervention group was lower than that of the control group[MD=-3.77,95％CI:(-4.39,-3.24),P＜0.000 01],the AQ score was higher than that of the control group[MD=9.88,95％CI:(8.70,11.05),P＜0.000 01],the ADL score was higher than that of the control group[MD=4.77,95％CI:(4.32,5.23),P＜0.000 01],the total clinical effective rate was higher than that of the control group[OR=6.03,95％CI:(4.25,8.54),P＜0.000 01],and the occurrence of adverse reactions there was no significant difference in the rate[RR=0.87,95％CI:(0.45,1.67),P=0.68].GRADE shows that the quality of evidence is generally not high.Conclusion:Butylphthalide can be used to treat aphasia patients after acute and non-acute cerebral infarction.
Keywords：butylphthalideaphasia after cerebral infarctionNIHSS scoreMeta-analysis
Publication Date：2024-09-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：12( 1840-1851 )