Research progress in 1-deoxynojirimycin derivatives with hypoglycemic activity
YAN Ken
LI Guang-yao
WEN Jun
ZHANG Hui-lan
HUANG Peng
HUANG He-ping
Abstract：1-deoxynojirimycin is a polyhydroxypyridine alkaloid with various pharmacological activities.As a strong inhibitor of α-glucosidase,it has been widely studied in the field of hypoglycemia.In order to enhance its specificity and further increase its hypoglycemic activity,researchers mainly modify the structure of 1-deoxynojirimycin through principles of assembly,structural hybridization,and valence state enhancement.This article mainly summarized N-substituted 1-deoxynojirimycin derivatives with hypoglycemic activity in recent years,providing reference for their application in hypoglycemic therapy.
Keywords：1-deoxynojirimycinα-glucosidasehypoglycemicresearch progress
Publication Date：2024-09-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：9( 1778-1786 )