Adverse reaction analysis of mesalazine in the treatment of inflammatory bowel disease
ZHANG Meng-yuan
LIU Yi-jing
ZHU Lei
Abstract：Inflammatory bowel disease(IBD)is a chronic,non-specific inflammatory bowel disease of unknown pathogenesis,and most of the patients require long-term medication.Mesalazine,belonging to 5-aminosalicylic acid(5-ASA)derivatives,is a first-line drug for clinical treatment of inflammatory bowel disease,which is used as induction and maintenance therapy to reduce intestinal inflammatory responses.It is usually well adapted.However,mesalazine also exposed some adverse reactions such as gastrointestinal adverse reactions,leukopenia,hepatic impairment,pancreatitis,pulmonary toxicity and nephrotoxicity,which involve multiple systems and are uneasy to distinguish from the complications of IBD.The purpose of this article is to summarize the adverse reactions of mesalazine and their corresponding clinical characteristics,so as to provide reference for correctly identifying and avoiding the occurrence of adverse events in clinical application,in order to achieve the purpose of treatment safety.
Keywords：mesalazine5-aminosalicylic acidinflammatory bowel diseaseadverse reaction
Publication Date：2024-08-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 1628-1632 )