Literature analysis of cutaneous adverse drug reactions induced by enfortumab vedotin
LING Cai-se
YIN Yue
LIN Mao
ZHOU Qi-ji
ZHANG Yan-hua
Abstract：Objective:To investigate the regularity of cutaneous adverse drug reactions(CADR)and clinical features of enfortumab vedotin(EV)in order to provide reference for safe and rational drug use.Methods:Case reports of the CADR induced by EV were retrieved from the databases of CNKI,Wanfang,VIP,Pubmed,and Web of Science.Results:A total of 30 cases were reported in 15 studies,including 28 males and 2 females,aged from 59 to 78 years.The CADR occurred between days 1 and 44.In 11 patients diagnosed with toxic epidermal necrosis syndrome(SJS)or toxic epidermal necrosis(TEN),the main pathological feature was a large number of keratinocyte necrosis or apoptosis,and the clinical manifestations were large erythema and bullosa throughout the body,involving the mucous membranes of the mouth,eyes,nose and genitals.For the other 19 patients with CADR,the clinical manifestations and pathological characteristics were different and atypical,and the severe cases were similar to SJS/TEN,while some mild patients only showed systemic pruritus with rash.Glucocorticoids are currently the main drugs used to treat EV-induced CADR,but the overall effect is poor,and 13 patients(43.3％)died after treatment.Conclusion:It is necessary to strengthen the understanding and monitoring CADR induced by EV and timely perform diagnosis and treatment to ensure medication safety.
Keywords：enfortumab vedotincutaneous adverse drug reactionsliterature analysis
Publication Date：2024-06-30
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：8( 1289-1296 )