Research progress in radiolabelling synthesis of[18F]FDOPA
PENG Can
DONG Guo-sheng
LI Xi-chen
LI Zheng
HAN Yu-fei
ZHANG Tao
Abstract：The PET radiotracer,[18F]6-fluoro-3,4-dihydroxy-L-phenylalanine([18F]FDOPA),is widely used to image dopamine metabolism in central nervous system diseases.However,the radiosynthesis of[18F]FDOPA in high radiochemical yields and specific activities is quite challenging.In recent years,with the widespread application of[18F]FDOPA in malignant diseases such as brain tumors,neuroendocrine tumors,and focal hyperin-sulinemia in infancy,there is an urgent need to develop improved synthetic approaches for[18F]FDOPA to fulfill growing clinical demands.This review summarizes the research progress of radiosynthetic process of[18F]FDOPA and introduces radiochemical yields,specific activities,enantiomeric purities,and synthesis time of[18F]FDOPA from different radiolabeling strategies in details.This review could be a reference for optimization of[18F]FDOPA radiosynthesis to obtain[18F]FDOPA with high radiochemical yield and purity as well as high specific activity which is suitable for clinical studies.
Keywords：[18F]6-fluoro-34-dihydroxy-L-phenylalaninepositron emission tomographyradiochemical synthesisradiochemical yieldcentral nervous system diseases
Publication Date：2024-06-30
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：10( 1233-1242 )