Literature analysis of adverse drug reactions related to nirmatrelvir/ritonavir
ZHANG Yi-nan
WU Ming-fen
LI Cao
ZHAO Zhi-gang
Abstract：Objective:To analyze the characteristics of adverse drug reactions(ADRs)related to nirmatrelvir/ritonavir in order to provide references for rational clinical drug use.Methods:The databases of CNKI,Wanfang,VIP,PubMed and Web of Science were searched to collect case reports of ADR related to nirmatrelvir/ritonavir from the establishment of the database up to January 2023.The literature was extracted for statistical analysis.Results:A total of 17 articles were included,involving 18 patients,6 males and 12 females.The age of the patients ranged 14 to 80 years,with the highest proportion in the age group of 71～80 years.ADRs occurring in neural and cardiac systems from 2 cases were suspected caused by nirmatrelvir/ritonavir.ADRs in sixteen cases were induced by the drug-drug interaction of nirmatrelvir/ritonavir.Drugs that are involved in the drug interactions were immunosuppressants in 11 cases,calcium channel blockers in 2 cases,antineoplastic agents,antipsychotics,and lipid modifying agent in 1 case each.All patients were cured after drug withdrawal or receiving symptomatic and supportive treatment.Conclusion:The safety of nirmatrelvir/ritonavir still requires further monitoring and study.Attention should be paid to possible drug interactions in clinical use to reduce the occurrence of adverse reactions.
Keywords：nirmatrelvirritonavirCOVID-19adverse drug reactiondrug-drug interaction
Publication Date：2024-05-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：9( 952-960 )