Literature analysis of adverse drug reactions induced by baricitinib
LIU Li-hua
LI Mei-yun
DING Ling
HU Jian
ZHANG Zi-fan
ZHANG Yu-min
Abstract：Objective:To analyze the clinical characteristics of adverse drug reactions(ADRs)induced by baricitinib.Methods:The databases of CNKI,Wanfang,VIP,Pubmed and Web of Science were searched up to March 2023,and the ADRs induced by baricitinib were collected and descriptively analyzed.Results:Totally 24 literatures were included,involving25 cases(12 males and 13 females),with an average age of 54.48±17.61(8～86)years.Most ADRs occurred within 3 months(68.00%).Infections(viral and fungal infections)and skin and its appendages damage accounted for the highest proportion,followed by bleeding and coagulation system damage and musculoskeletal damage.Most patients improved after discontinuation of medication and symptomatic treatment,and one case had a poor prognosis due to the progression of primary disease.Conclusion:The adverse reactions of baricitinib can affect multiple systems/organs,and monitoring should be strengthened to improve the safety of patients.
Keywords：baricitinibadverse reactionsliterature analysis
Publication Date：2024-04-30
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 844-848 )