Analysis of the clinical characteristics of adverse reactions associated with cadonilimab
LI Jin-lan
PAN Yong
ZENG Mei-zi
CHEN Shan-shan
Abstract：Objective:To analyze the incidence and clinical characteristics of adverse drug reactions(ADRs)caused by cardinirimab,so as to provide reference for clinical rational drug use.Methods:From January 2021 to December 2022,the medical records of 18 inpatients with ADRs caused by cardonirimab in our hospital were retrospectively analyzed.Results:Among the 18 cases of cardonirimab-related ADRs,12 were males(66.67％),6 were females(33.33％),the median age of onset was 64 years,and the primary disease was lung cancer(14 cases,77.78％).The main clinical manifestations were rash and itching,immune-related thyroid dysfunction,immune-related hypophysitis,and immune-related myocarditis.The median occurrence time of immune-related hepatitis and hypothyroidism ADRs were 11 weeks and 12 weeks respectively,the median occurrence time of immune-related pneumonia was 19.7 weeks after administration,and the median occurrence time of encephalitis was 43.3 weeks;the median occurrence time of myocarditis and hypophysitis was about 30 weeks;the median time of skin toxicity was 6.1 weeks.All ADRs were cured or improved after symptomatic and supportive treatment,and there was no death related to adverse events.Conclusion:When using cardonirimab in clinical practice,it is necessary to strengthen the monitoring of ADRs to ensure the safe and effective drug use.
Keywords：cadonilimabadverse reactionsprogrammed cell deathreceptor-1cytotoxic T-lymphocyte-associated protein-4 inhibitorclinical features
Publication Date：2024-03-31
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 619-624 )