Comparison of the properties of Pfaffia glomerata extract powder processed by different drying methods
GAO Jian
HUANG Lu-qi
LI Zhe
DONG Huan-huan
CHEN Li-hua
Abstract:Objective:To compare the properties of Pfaffia glomerata extract powder processed by vacuum drying,hot air drying and spray drying,as well as study the best drying method.Methods:The flowability,stability,compressibility and other properties of powder were characterized by multiple indicators such as particle size,water content,bulk density,tap density,repose angle,etc.;scale-up validation was carried out on the preferred drying methods.Results:The correlation coefficients between three drying methods and control atlas were 0.798,0.827 and 0.698,respectively;the cluster analysis classified hot air drying and vacuum drying into class I,indicating that the properties were similar;the Pearson correlation coefficient of spray drying powder between pilot test and laboratory was 0.978.Conclusion:The spray drying powder has obvious differences compared with that processed by the other two drying methods,which has excellent flowability and is not easy to agglomerate;the compression ability of the products by hot air drying and vacuum drying is better.The spray drying powder is stable in the scale-up validation,suggesting that this method can realize large-scale production of Pfaffia glomerata extract powder.
Keywords:Pfaffia glomeratadrying processphysical propertiespowder mobilitysolid preparation
Publication Date:2024-02-29
Online Publishing Date:2026-08-14(First online date of this platform, not the publication date of the document)
Pages:7( 383-389 )
Chinese Journal of New Drugs

Chinese Journal of New Drugs

ISSN:1003-3734
Year, Vol.(Issue):2024,33(4)