A comparison of the effects of methylphenidate extended-release tablets and atomoxetine on sleep parameters in patients with attention deficit hyperactivity disorder
WU Wei-ge
WANG Wen-qiang
LI Zong-lei
LI Yun
WEI Xuan
ZHENG Shu-chuan
Abstract：Objective:To compare the effects of methylphenidate sustained-release tablets and atomoxetine on sleep in patients with attention deficit hyperactivity disorder(ADHD).Methods:A total of 70 patients with ADHD were enrolled and randomly divided into methylphenidate sustained-release tablets(MPH)and atomoxetine(ATX)treatment groups according to a random number table.Overnight polysomnography(PSG)was performed at baseline and the end of 2 and 6 weeks of medication.Results:Totally 48 patients with ADHD(23 in the MPH group,65.7%;25 in the ATX group,71.4%)completed a total of 3 PSGs.At baseline,there was no significant difference in the values of each sleep parameter between the MPH group and the ATX group(P>0.05).At the end of 2 weeks,the sleep onset latency(SOL),REM onset latency(ROL)of the MPH group were longer than those of the ATX group;the REM time was shorter than that of the ATX group;the sleep efficiency SE(%)was worse than that of the ATX group,and the differences were statistically significant(P<0.05 for all).At 6 weeks,there was no significant difference in SOL,ROL,REM time and sleep efficiency SE(%)between the MPH group and the ATX group(P>0.05).The percentage of total sleep time(%TST)for N1,N2,N3 and R stages and the number of awakenings and wake after sleep onset WASO were not significantly different between the two groups(P>0.05).Conclusion:Compared with the ATX group,the MPH group had a certain negative impact on the sleep condition of ADHD patients after 2 weeks of medication.There was no obvious difference in the effect on sleep between the two drugs after 6 weeks of continuous treatment.There was a certain correlation between the improvement of ADHD core symptoms and the improvement of sleep.Both MPH and ATX can be used as first-line drugs for treating ADHD patients with comorbid sleep problems.
Keywords：attention deficit hyperactivity disorderpolysomnographymethylphenidate sustained release tabletstomoxetine
Publication Date：2023-12-31
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 2535-2539 )