The latest research progress of daridorexant,a dual orexin receptor antagonist for insomnia
LI Xin-ru
SHENG Dan-dan
LIU Jing
LIU Wei-ping
Abstract：There are many kinds of drugs for insomnia,but the current hypnotics on the market cannot fully meet the clinical needs.As a new treatment for insomnia disorder,dural orexin receptor antagonist(DORAs)has a different mechanism of action from the traditional hypnotics,it can avoid a series of common side effects of traditional hypnotics and has a good safety profile.A newly developed dual orexin receptor antagonist,daridorexant,has been studied in a number of clinical studies in global,and data shows that it improves both the sleeping disorder at night and daily functions,with good safety feature.This review comprehensively summarizes the efficacy,safety,and clinical data of the dual orexin antibody antagonist daridorexant in various clinical trials.
Keywords：insomniasleep disordersdual orexin receptor antagonistdaridorexantpharmacology
Publication Date：2023-12-31
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：4( 2531-2534 )