A brief analysis of the focus of production capacity research of autologous CAR-T therapeutic products
WANG Xue
MA Yan-song
WEI Wei
HE Wu
Abstract：Autologous chimeric antigen receptor T cell(CAR-T)cell therapy products have brought significant survival benefits to tumor patients,especially in the treatment of hematologic tumors.However,the common production mode of autologous CAR-T therapy products is complicated and has a long cycle.As a result,the production capacity of this kind of products has limited their clinical application to a certain extent.In this paper,based on the analysis of the common production mode of autologous CAR-T cell products,the content and evaluation of the capacity confirmation study and capacity change study of autologous CAR-T therapeutic products are proposed in combination with the current research progress,hoping to effectively promote the development and clinical application of such products.
Keywords：autologous CAR-T cellsproduction capacity researchreview considerations
Publication Date：2023-12-31
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 2447-2451 )