Progress in target discovery and drug development for non-alcohol fatty liver disease
SUN Zhao-hui
YANG Zhen-zheng
ZHENG Xiao-nan
Abstract：Non-alcoholic fatty liver disease(NAFLD)is a common chronic metabolic disease characterized by the accumulation of fat in the liver.The onset and progression of NAFLD are associated with a variety of metabolic abnormalities,including obesity,diabetes mellitus,and hyperlipidemia.Due to its high prevalence and risk worldwide,NAFLD has become an important issue in public health.However,to date,treatments for NAFLD are very limited,with no relevant drugs approved for marketing in Europe,America,or China and clinical trials of new drugs have gained no progress in recent years.This paper reviews the therapeutic targets,clinical research progress of new drugs,and new treatment strategies for NAFLD,in addition to summarizing the reasons for the high failure rate of NASH clinical trials and proposing corresponding solutions,aiming at providing ideas and reference for new drug development.
Keywords：non-alcoholic fatty liver diseasenon-alcoholic steatohepatitisclinical trialstreatment strategiesnew targets
Publication Date：2023-12-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：9( 2394-2402 )