Effects of Dendrobium nobile Lindl wall-broken powder on tumor growth and immune function of tumor-bearing mice
SHUI Lin
LIU Ming-hua
SHUI Pi-xian
SUN Qin
ZHUANG Yuan-chun
Abstract：Objective: To study the effects of Dendrobium nobile Lindl wall-broken powder on the tumor growth and immune function of tumor-bearing mice. Methods: The antitumor activity of Dendrobium nobile Lindl wall-broken powder in vivo was observed by the models of implanted H22 and S180 in mice. The effect of Dendrobium nobile Lindl wall-broken powder on the immune function of tumor-bearing mice was investigated by using phagocytosis test. T lymphocyte proliferation test and ELISA, which were used to observe the expression levels of IL-2, IL-6, IL-12 and TNF-α. Results: At dosage of 0. 5, 1. 0 and 2. 0 g·kg-1, the inhibition rates of Dendrobium nobile Lindl wall-broken powder were 16. 33％, 31. 63％, 57. 14％ for S180, and 20. 67％, 39. 12％, 55. 87％ for H22, respectively. Dendrobium nobile Lindl wall-broken powder could increase spleen index and chest gland index, improve the phagocytosis function of macrophages, enhance T lymphocytes proliferation, and increase the expression levels of IL-2, IL-6, IL-12 and TNF-α in serum. Conclusion: Dendrobium nobile Lindl wall-broken powder exhibited significantly anti-tumor effect in vivo and the mechanism may be related to enhancing immune function.
Keywords：Dendrobium nobile Lindl wall-broken powdertumor-bearing miceimmune functionS180H22
Publication Date：2018-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 1896-1901 )