Effect of intravenous esomeprazole on gastric acid secretion in rats
ZHU Lin-wensi
XUE Jin-hui
XIONG Hua
FANG Jing-yuan
Abstract：Objective: To compare the effects of generic (Aisuping()) and original intravenous esomeprazole (Nexiumumumumum()) on gasctric acid secretion. Methods: Ninety-three SD rats were randomly divided into six groups, including Aisuping() Low-dose group ( 10 mg·kg-1·d-1), Aisuping high-dose() Group ( 50 mg·kg-1·d-1), Nexium() Low-dose group ( 10 mg·kg-1·d-1), Nexium() High-dose group ( 50 mg·kg-1·d-1), saline group and blank group.Then, the secretion levels of gastric acid, pepsin and gastrin were detected on day 5 and day 14 after the multiple dose administration. Results: There was no significant difference in the secretion levels of gastric acid, pepsin and gastrin between Aisuping() And Nexium() Groups on day 5 and day 14. Both Aisuping() And Nexium() Could effectively inhibit gastric acid secretion in rats. Conclusion: Generic esomeprazole for injection has long and persistent gastric acid inhibitory effect in rats, which is equivalent to original esomeprazole.
Keywords：intravenous esomeprazoleratsgastric acid secretionpepsingastrin
Publication Date：2018-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：4( 1892-1895 )