Efficacy and safety of compound Cortex Phellodendri Liquid for diabetic foot ulcer: a Meta-analysis
WANG Ning
JU Shang
YANG Bo-hua
WANG Gang
LIAN Xiao-tong
GAO Yu
ZHANG Xiao-fu
CAO Xin
YAN Cheng-cheng
YAO Li-li
LI Rong-rong
ZHANG Ding-kun
Abstract：Objective: To conduct a meta-analysis to evaluate the clinical efficacy and safety of Compound Cortex Phellodendri Liquid for treatment of diabetic foot ulcer (DFU). Methods: Databases including Pub Med, EMBASE, The Cochrane Library, CBM, CNKI, Wanfang and VIP data were searched to collect randomized controlled trials (RCTs) about Compound Cortex Phellodendri Liquid in the treatment of DFU from inception to March 2018. Two reviewers independently evaluated the quality of the included studies and extracted the data.Meta-analysis was systematically reviewed by using Rev Man 5. 3 statistical software. Results: A total of 11 RCTs involving 2 147 patients were included. The result of meta-analysis showed that, compared with control group, Compound Cortex Phellodendri Liquid produced a statistically significant improvement for a higher effective rate in DFU (RR = 1. 28, 95％ CI: 1. 17 ～ 1. 41). Six trials revealed that no serious adverse event was related to the use of the drug. Conclusion: Compound Cortex Phellodendri Fluid is an effective and safe external preparation for treating DFU. More high-quality RCTs need to be carried out to confirm the present findings.
Keywords：Compound Cortex Phellodendri Liquiddiabetic footefficacysafetyMeta-analysis
Publication Date：2018-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 1771-1775 )