Research on the clinical expressions of tyrosine kinase receptor EphA2 in the human brain astrocytoma and its correlation with the genesis of tumor vessels
SUN Xin-lin
WANG Ji-hui
JIN Fa
HUANG Min
KE Yi-quan
Abstract：Objective: To analyze the clinical expressions of tyrosine kinase receptor EphA2 in the human brain astrocytoma and its correlation with the genesis of tumor vessels. Methods: 44 patients with human brain astrocytoma treated from September 2014 to September 2017 in our hospital were selected as study group; 6 cerebral hemorrhage patients who need lobectomy were selected as control group. Through the Western Blot and immunohistochemical method, the clinical expressions of EphA2 in the human brain astrocytoma and the microvessel density (MVD) were observed. Results: The EphA2 proteins were majorly distributed in the tumor cell cytoplasm and membrane. EphA2 proteins were not detected only in 4 cases of low-grade astrocytoma, and they were detected in the other astrocytoma cases. The positive rate of EphA2 was 90. 91％. The EphA2 proteins were not detected in the normal cerebral tissues. The EphA2 expressions for two groups were significantly different (P＜0. 05). For low-grade (Grade Ⅰ ～ Ⅱ) and high-grade (Grade Ⅲ ～ Ⅳ) astrocytoma, the MVD of patients with Grade 0 ～ 3 staining degree was significantly different (P＜0. 05). The MVD ranged from high to low: Grade 3, Grade 2, Grade 1 and Grade 0 (P＜0. 05). In the human brain astrocytoma, the EphA2 expressions, pathological grading and staining degree were positively correlated with the MVD (P＜0. 05). Conclusion: The EphA2 protein expressions have an obvious correlation with the pathological grading and malignant degree as well as the genesis of tumor microvessel.
Keywords：human brain astrocytomatumor vesseltyrosine kinase receptor
Publication Date：2018-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 1762-1766 )