Change of cytokines in patients with helicobacter pylori negative gastric ulcers after treatment of rebamipide
LIU Xin-yao
WANG Xiao-hui
WANG Shao-xin
YAN Zhi-hui
LUO Zhe
CUI Li-hong
Abstract：Objective: To analyze the therapeutic effect of rebamipide for helicobacter pylori (Hp)negative gastric ulcers, and observe the change of cytokines after treatment. Methods: Ninety Hp negative gastric ulcer patients were chosen, who were diagnosed by endoscopy and 13C urea breath test, and divided into PPI group, bismuth+PPI group and rebamipide+PPI group randomly. The three groups received pantoprazole alone, pantoprazole plus bismuth and rebamipide plus pantoprazole separately for 4 weeks. The effect of the treatment and the levels of cytokines after the treatment were compared among the three groups. Results: The rebamipide + PPI group achieved a better effect than the PPI group. And the levels of IL-1, IL-6, and MDA of the rebamipide+PPI group were significantly lower than those of the other two groups, while the levels of EGF, PGE2, NO and VEGF were significantly higher (P <0. 05 ). Conclusion: Rebamipide is effective for the treatment of Hp negative gastric ulcers. And rebamipide can reduce the levels of aggressive factors and increase the systhesis of protective factors.
Keywords：gastric ulcercytokinerebamipide
Publication Date：2018-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：4( 910-913 )