Application progress of nonhuman primate models for drug addiction research and the significance
WANG Qi
CHEN Ying
OUYANG Zhao-he
WU Chun-qi
ZHANG You-zhi
WANG Xiao-fei
WANG Quan-jun
Abstract：Drug addiction is a chronic, relapsing brain disorder, which not only induces a lot of serious body and psychological damages to addicts themselves, but also induces criminal activities with a threat to social and public safety. Therefore, it is important to select appropriate animal models for the study of the mechanism of drug addiction. At present, animal species commonly used in addiction research are rats, mice, monkeys and so on. Nonhuman primates (NHPs)are the closest relatives of humans, and the physiology, anatomy and behavior of NHP are more similar to humans than other laboratory species. Their long life span, well suited to long-term drug addiction research, can better simulate the pathological process of drug addiction and relapse in humans. In the study of addiction, NHPs have an irreplaceable important position. This article mainly reviewed the commonly used nonhuman primate models of drug addiction and their advantages, especially focused on the application and characteristics of nonhuman primates in the studies of withdrawal, conditional place preference, behavioral sensitization and self-administration, and briefly introduced the application of neuroimaging technology in this field.
Keywords：drug addictionanimal modelnonhuman primateneuroimaging technology
Publication Date：2018-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 858-863 )