Research on genotoxicity of chainamide compounds B07
LI Shu-fang
QIN Xiu-jun
XU Wen-li
YIN Jing-jing
YUE Juan
WANG Xin-gang
LI Jian-guo
AN Quan
Abstract：Objection:To evaluate the genotoxicity of chainamide compounds B07.Methods:The genotoxicity of B07 was studied by Ames test,chromosomal aberration test in Chinese hamster lung (CHL) cell and micronucleus test in rat bone marrow.Results:In Ames test,at concentration of 5 000 μg· plate-1,the reversal colonies in TA102 were increased (P ＜ 0.01) compared with negative control.At concentration of 0.5 ～ 500 μg·plate-1,the reversal colonies in TA102 were not increased.At concentration of 0.5 ～ 5 000 μg·plate-1,the reversal colonies in TA97,TA98,TA100 and TA1535 were not increased.In chromosomal aberration test,B07 did not induce a significant increase in the rate of CHL cell chromosomal aberrations at concentration of 75 ～ 600 μg· mL-1 Micronucleus test indicated that B07 had no mutation effect on the rate of rat micronucleated polychromatic erythrocytes at dose of 1.6 ～ 6.4 mg· kg-1.Conclusion:B07 in high dose may cause gene mutation.
Keywords：chainamide compounds B07genotoxicityAmes testchromosomal aberration testmicronucleus test
Publication Date：2018-02-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 295-299 )