Detection and evaluation of dasatinib-induced respiratory system ADR signals in post-marketing experience
TIAN Ya-lan
BIAN Gui-zhi
CAO Pei
ZHANG Zhi-yong
Abstract：Objective:To detect and analyze the ADR signals of dasatinib in post-marketing experience,and provide references for clinic.Methods:Reporting odd ratio (ROR) algorithm was used to investigate the ADR signals from AERS submitted to the U.S.FDA,and the effects of gender,age,medication duration and dosage were analyzed by SPSS 19.0.Results:A total of 76 982 127 reports were found for all drugs,among which 11 461 reports suspected that dasatinib was the primary drug causing the ADR.After detection,343 signals related to dasatinib were identified,including 26 signals relevant to respiratory,thoracic and mediastinal disorders.There existed significant difference in the gender (P =0.003),age (P =0.000) and medication duration (P =0.000),but not in the dosage (P =0.911) of the 26 signals compared with other ADRs.Conclusion:There exist risks of respiratory,thoracic and mediastinal disorders when taking dasatinib,so corresponding preventive measures should be taken in clinical application.
Keywords：dasatinibadverse drug reactionssignal detectionreasonable administration
Publication Date：2018-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 236-241 )