Preparation and in vitro release of asenapine maleate-loaded microspheres
ZHOU Xiang-ping
HE Dong-mei
YANG Juan
MO Jian-mei
CHEN Xin-tong
GUAN Shi-xia
Abstract：Objective:To prepare asenapine maleate (ASM)-loaded microspheres,and evaluate their in vitro characteristics.Methods:ASM microspheres were prepared by O/W emulsion-solvent evaporation method.The effects of different polymers on microspheres were investigated.Results:ASM microspheres prepared with PLGA 75/25 were spherical and smooth.The particle size was 83.54 μm,the encapsulation efficiency was 86.39％,and the drug loading was 12.19％.The release of ASM was completed at a constant or nearly constant speed within 40 days,and the zero-order release curve was as follows:Y =0.022 63X + 0.111 45,r =0.986 2.Conclusion:ASM microspheres prepared by emulsion-solvent evaporation method PLGA 75/25 can sustainedly release ASM in vitro for 40 days,which may achieve long-term therapeutic effect and improve the bioavailability.
Keywords：asenapine maleatemicrosphereemulsion-solvent evaporation methodsustained release
Publication Date：2018-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 220-224 )