Preparation of pantoprazole sodium bioadhesive tablets
SUN Tao-li
JIANG Mei
JIANG Yao
LIU Wei-ping
WU Zhu
WEI Quan-min
TANG Jing
WANG Jian-fen
MA Ning
Abstract：Objective:To prepare pantoprazole sodium (PAZ-Na) bioadhesive tablets and investigate the drug release in vitro and adhesion force.Methods:The PAZ-Na bioadhesive tablets were prepared with the bioadhesive material HPMCK4M,CP 934,lactose,sodium bicarbonate and anhydrous sodium carbonate.The formula was optimized using orthogonal design.The adhesive force for small intestinal mucosa of rats was measured by homemade adhesion measuring device.The paddle technique was used to measure the drug release rate of PAZ-Na from the tablets.Results:PAZ-Na bioadhesive tablets(0.2 g per tablet)were prepared using the following optimal formula:PAZ-Na 3.1 g,HPMCK4M 4.0 g,CP 934 0.75 g,lactose 7.5 g,1.0％ anhydrous sodium,and carbonate magnesium stearate of appropriate amount.The cumulative drug release rates of 3 batches of samples were above 90％ in 12 h.Conclusion:PAZ-Na bioadhesive tablets prepared in this study showed ideal bioadhesive force and drug release behavior,which would provide a reference for development of new PAZ-Na formulations.
Keywords：pantoprazole sodiumbioadhesive tabletsbioadhesive forcedrug release in vitro
Publication Date：2018-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 214-219 )