Design and evaluation of dual targeting multifunctional nanocarrier
SONG Xiao-yan
WANG Xiao-ying
QI Meng-jiao
DONG Xue
WANG Kai-li
GUO Chun-jing
CHEN Da-quan
Abstract：Objective:To develop and evaluate dual CD44 receptor and folate receptor targeting pH-sensitive nanocarrier.Methods:The smart response muhifunctional oligomeric hyaluronic acid conjugate,folic acidoligomeric hyaluronic acid-acetal-menthone 1,2-glycerol ketal (FA-oHA-Ace-MGK),was synthesized by chemical reaction.The pH-sensitive Ace-MGK as hydrophobic moieties,oHA as the target of CD44 receptor and FA as the target of folate receptor.The structure of this dual CD44 receptor and folate receptor targeting smart response multifunctional nanocarrier was confirmed with Fourier-transform infrared and nuclear magnetic resonance (1H-NMR).The micelles of this nanocarrier were loaded with curcumin (Cur),a model drug,by dialysis method,and were characterized by mean diameter,zeta potential and morphology visualized by transmission electron microscopy (TEM).Results:FoAM nanocarrier was synthesized successfully.Drug-loaded FoAM could self-assemble to form spherical nanoparticles with the mean diameter of 158.2 nm and zeta potential of-24.51 mV.Conclusion:FoAM,as an effective nano-size carrier,has a promising potential for anti-tumor drug delivery.
Keywords：dual targetingmultifunctionpH-sensitivitytargeting carrier
Publication Date：2018-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：7( 207-213 )