Preparation and in vitro release of piroxicam-benzoic acid cocrystal
ZHANG Yue-yong
TIAN Jia-xin
L(U) Lin
LAN Ya-ru
ZHANG Lei
GUO Yong-xue
Abstract：Objective:This experiment adopted the eutectic technology for preparation of insoluble drug piroxicam eutectic materials,in order to improve the solubility of insoluble drugs and dissolution.Methods:Piroxicam cocrystal with benzoic acid was prepared by cooling crystallization method to improve the solubility and bioavailability of piroxicam drug.The cocrystal was characterized by high performance liquid chromatography,differential scanning calorimetric (DSC) and X-ray powder diffraction (XRPD).Meanwhile,the solubilities and dissolution properties of piroxicam and cocrystal were determined by digital tachometer temperature water bath oscillator and intelligent dissolution apparatus.Results:The cocrystal formation of piroxicam with benzoic acid has been prepared successfully,and displayed higher solubility and better release in vitro than piroxicam.Conclusion:The cocrystal technology has broad application prospects in improving solubility and dissolution of poorly soluble drugs.
Keywords：proxicamdrug cocrystalmixed solvent crystallizationsolubilityrelease in vitro
Publication Date：2018-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 91-96 )