Finding of a new solvent-free polymorph of mifepristone
XU Juan
HU Biao
WANG Hui-ping
CHEN Xiao-feng
LI Peng
NING Li-feng
Abstract：Objective:To investigate polymorphism of the contraceptive mifepristone.Methods:Kinds of physical or chemical methods were used to assess mifepristone polymorphs.These polymorphs were characterized by X-ray powder diffraction analysis (PXRD),differential scanning calorimetry (DSC),thermogravimetric analysis (TG) and infrared absorption spectroscopy (IR).A variety of influence factors were assessed to determine the stability of the polymorphs.The solubility curves were drawn in 6 solvents.Results:A new crystal form of mifepristone was discovered,and it had significant differences from mifepristone in PXRD,DSC and TG.The new polymorph was stable under high temperature,high humidity and strong light.The new polymorph had higher solubility than mifepristone in 0.2％ SDS and 0.5％ SDS.Conclusion:The polymorphism of mifepristone has been demonstrated.The new solvent-free polymorph has better solubility than mifepristone and they can be identified by PXRD,DSC and TG.
Keywords：mifepristonepolymorphismuseful characterization methods for polymorphs
Publication Date：2018-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 78-83 )