Perioperative neural protection of dexmedetomidine on patients undergoing liver transplantation

SHAN Zhi-ming; XU Yi-xin; XIU Huan-huan; ZHANG Yong; ZHAO Yue; XU Kang-qing

Abstract：Objective:To evaluate the perioperative neural protection of dexmedetomidine on patients undergoing liver transplantation.Methods:Eighty patients undergoing liver transplantaion in our hospital were randomly divided into two groups:group D and group C.Patients in group D were administered with dexmedetomidine at 1 μg· kg-1 by bolus injection in 10 min,followed by iv pumping at the rate of 0.5 μg· kg-1· h-1 till the end of surgery.Patients in group C were administered normal saline instead of dexmedetomidine.Arterial blood samples were obtained before anesthesia (T1),before hepatectomy (T2),non-liver period (T3),new liver period (T4),and at the end of surgery (T5) to analyze CaO2,Da-jvO2 and CERO2,and venous blood samples were collected to measure S100β and neuron specific enolase (NSE).Hemodynamics during surgery was recorded.MMSE scale were obtained before and after surgery.Results:The patients in group D showed more stable hemodynamics than those in group C during T3 and T4.The CERO2 values of patients in group D were much lower than those in group C during T3 and T4.The S100β and NSE levels of patients in group D were much lower than those in group C during T3 and T4.The MMSE scales of patients in Group D were much higher than those in group C after surgery.Conclusion:Dexmedetomidine can partially stabilize the hemodynamics,decrease cerebral oxygen extraction rate,inhibit the release of S100β and NSE,and improve patients' neural function after liver transplantation surgery.